Rotavirus and adenovirus in the canton of Ambato, a retrospective post-pandemic analysis
DOI:
https://doi.org/10.56294/sctconf2024552Keywords:
Rotavirus, Adenovirus Intestinal Infection, MalnutritionAbstract
Introduction: intestinal infections are one of the causes that most frequently bring patients under 6 years of age to primary health care systems. In Ecuador, given the cultural and hygienic conditions, they are linked to malnutrition, especially in rural areas, causing poor performance and absenteeism at school for children and wear and tear on their caregivers.
Objective: to determine the presence of Rotavirus and Adenovirus in patients attending a laboratory in the city of Ambato from 2018 to 2023.
Method: the research was descriptive and longitudinal with a total of 3330 patients between 1 day old and 80 years old. The detection method used was qualitative lateral flow immunoassay of Certest, Healgen and Operon brands. Added to this information obtained by literature search in sources such as Researchgate, Google Scholar, SciELO, PubMed, Elservier, BVS, Dialnet, Science Direct from 2018 to 2024.
Results: the prevalence of Rotavirus was (69,28 %) relative to that of Adenovirus (30,72 %) ( p<0,0001). The rate of Rotavirus antigens in the year 2023 was higher for children between 1 day old and 5 years (76 %) than that detected in children for Adenovirus (24 %) (p<0,0001).
Conclusions: the presence of viral agents is considered moderate considering that the study population was urban, an increase in the number of cases from 2018 to 2023 is evident, which makes it necessary to review public health policies in order to reduce the number of times this pathology is repeated
References
1. Medigraphic.com. [citado el 1 de marzo de 2024]. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=101267
2. Poulain C, Galeno H, Loayza S, Vergara N, Valdivieso F, Coria P, et al. Detección molecular de patógenos entéricos en niños con diarrea en un hospital centinela de vigilancia de rotavirus en Chile. Rev Chilena Infectol [Internet]. 2021 [citado el 1 de marzo de 2024];38(1):54–60. Disponible en: https://www.scielo.cl/scielo.php?pid=S0716-10182021000100054&script=sci_arttext&tlng=en
3. Blanco-Díaz MA, Reyes-Romagosa DE. Análisis estadístico de la enfermedad diarreica aguda en pacientes atendidos en servicio de urgencias durante el 2012-2013. Rev Cubana Investig Bioméd.2024; 34(2):104-11. Disponible en: http://scielo.sld.cu/pdf/ibi/v34n2/ibi01215.pdf.
4. Van Gaalen RD, Van de Kassteele J, Hahné S, Bruijning-Verhagen P, Wallinga J. Determinants of Rotavirus Transmission A Lag Nonlinear Time Series Analysis. Epidemiology.2017;28(4): 503-13. doi: https://10.1097/EDE.0000000000000654.
5. Comas GA, Reyes GU, Reyes HKL, et al. Gastroenteritis en niños por otros agentes virales diferentes al rotavirus. Enf Infec Microbiol. 2020;40(3):100-107.
6. Ojobor CD, Olovo CV, Onah LO, Ike AC. Prevalence and associated factors to rotavirus infection in children less than 5 years in Enugu State, Nigeria. Virusdisease. 2020; 31(3):316-22. https://doi.org/10.1007/s13337-020-00614-x.
7. Gallardo J, Pérez-Illana M, Martín-González N, San Martín C. Adenovirus structure: What is new? Int J Mol Sci [Internet]. 2021 [citado el 1 de marzo de 2024];22(10):5240. Disponible en: https://www.mdpi.com/1422-0067/22/10/5240
8. Kulanayake S, Tikoo S. Adenovirus core proteins: Structure and function. Viruses [Internet]. 2021 [citado el 1 de marzo de 2024];13(3):388. Disponible en: https://www.mdpi.com/1999-4915/13/3/388
9. Fitzgerald SD, Rautenschlein S, Mahsoub HM, Pierson FW, Reed WM, Jack SW. Adenovirus Infections [Internet]. Diseases of Poultry. Wiley; 2020. p. 321–63. Disponible en: http://dx.doi.org/10.1002/9781119371199.ch9
10. Manwill K, Klein FG, Wang D, Hindupur SV, Ehrenfeld M, Holm PS, et al. Concepts in oncolytic Adenovirus therapy. Int J Mol Sci [Internet]. 2021 [citado el 1 de marzo de 2024];22(19):10522. Disponible en: https://www.mdpi.com/1422-0067/22/19/10522
11. Gutierrez Sanchez LH, Shiau H, Baker JM, Saaybi S, Buchfellner M, Britt W, et al. A case series of children with acute hepatitis and human Adenovirus infection. N Engl J Med [Internet]. 2022;387(7):620–30. Disponible en: http://dx.doi.org/10.1056/nejmoa2206294
12. Geletu US, Usmael MA, Bari FD. Rotavirus in calves and its zoonotic importance. Vet Med Int [Internet]. 2021 [citado el 1 de marzo de 2024];2021:1–18. Disponible en: https://www.hindawi.com/journals/vmi/2021/6639701/
13. Caddy SL, Vaysburd M, Wing M, Foss S, Andersen JT, O‘Connell K, et al. Intracellular neutralisation of rotavirus by VP6-specific IgG. PLoS Pathog [Internet]. 2020;16(8):e1008732. Disponible en: http://dx.doi.org/10.1371/journal.ppat.1008732
14. Cobertura de inmunización [Internet]. Who.int. [citado el 8 de abril de 2024]. Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/immunization-coverage
15. Ballard S-B, Requena D, Mayta H, Sanchez GJ, Oyola-Lozada MG, Colquechagua Aliaga FD, et al. Enteropathogen changes after Rotavirus vaccine scale-up. Pediatrics [Internet]. 2022 [citado el 1 de marzo de 2024];149(1):e2020049884. Disponible en: https://publications.aap.org/pediatrics/article/149/1/e2020049884/183843/Enteropathogen-Changes-After-Rotavirus-Vaccine
16. Sadiq A, Bostan N, Khan J, Aziz A. Effect of rotavirus genetic diversity on vaccine impact. Rev Med Virol [Internet]. 2022;32(1). Disponible en: http://dx.doi.org/10.1002/rmv.2259
17. Paho.org. [citado el 8 de abril de 2024]. Disponible en: https://www3.paho.org/spanish/ad/fch/im/GuiaPractica_Rotavirus.pdf
18. Amimo JO, Raev SA, Chepngeno J, Mainga AO, Guo Y, Saif L, et al. Rotavirus interactions with host intestinal epithelial cells. Front Immunol [Internet]. 2021;12. Disponible en: http://dx.doi.org/10.3389/fimmu.2021.793841
19. Preguntas y respuestas: hepatitis aguda grave en niños [Internet]. Paho.org. [citado el 8 de abril de 2024]. Disponible en: https://www.paho.org/es/noticias/3-5-2022-preguntas-respuestas-hepatitis-aguda-grave-ninos
20. Organización Panamericana de la Salud . Vigilancia epidemiológica de diarreas causadas por rotavirus [Internet]. Organizacion Mundial de Salud. 2007 [citado el 2 de abril de 2024]. Disponible en: https://www3.paho.org/spanish/ad/fch/im/GuiaPractica_Rotavirus.pdf
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