Acute disseminated encephalomyelitis and not-associated active viral infection

Authors

DOI:

https://doi.org/10.56294/sctconf2023450

Keywords:

Acute Disseminated Encephalomyelitis, Viral Encephalitis, Demyelinating

Abstract

Introduction: Acute disseminated encephalomielitis (ADEM) is an autoinmune disorder of the central nervous system, which causes a broad inflammatory process in the brain and spinal cord. It is characterized by the association of acute encephalopathy and multiple neurological deficits, 1 or 2 weeks after an infectious process that will not always be evident or after an immunization.

Case report: A 52- year- old male patient presented with intense headache associated with disorder of consciousness, motor deficit, aphasia and active infection with herpes simplex virus type 1. Magnetic resonance imaging of the simple skull is performed showing hyperintense images of a demyelinating nature.

Conclusion: The diagnosis of a case of ADEM with an active acute infection truly constitutes an exceptional event and of great interest, considering that the etiology of this entity is 75 percent postinfectious. Identifying in time whether they are related pathologies or not determines the choice of treatment and evolution of the patient.

References

1. Wang, C.X. Assessment and Management of Acute Disseminated Encephalomyelitis (ADEM) in the Pediatric Patient. Pediatric Drugs.2021; 23:213-221. https://doi.org/10.1007/s40272-021-00441-7

2. Olivares F, Salinas M, Soto A, Dabanch J, Fica A. Encefalomielitis aguda diseminada grave. Comunicación de un caso asociado a infección por virus parainfluenza 3. Rev chilena. 2015; 32(4). http://dx.doi.org/10.4067/S0716-10182015000500019

3. Reichard R, Kashani KB, Boire NA, Constantopoulos E, Guo Y. Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology. Acta Neuropathol.2020; 140:1-6. https://link.springer.com/article/10.1007/s00401-020-02166-2

4. Berzero G, Cortese A, Ravaglia S, Marchioni E. Diagnosis and therapy of acute disseminated encephalomyelitis and its variants. Expert Review Neurotherapeutics .2016; 16:83-101. https://doi.org/10.1586/14737175.2015.1126510

5. Pohl D, Alper G, van Haren K, Kornberg A.J, Lucchinetti C.F, Tenembaum S et al. Acute disseminated encephalomyelitis: updates on an inflammatory CNS syndrome. Neurology. 2016; 87: 38-45. https://doi.org/10.1212/WNL.0000000000002825

6. Rodríguez-Montolio J, Ballesta-Martínez S, Martín-Alemán Y, Muñoz-Farjas E. Encefalomielitis aguda diseminada tras infección por Mycoplasma pneumoniae: evolución tórpida, recuperación excelente. Rev Neurología. 2022; 37(4):313-315. https://www.elsevier.es/es-revista-neurologia-295-articulo-encefalomielitis-aguda-diseminada-tras-infeccion-S0213485321000979

7. Expósito Escudero JM, Martin Viota L. Encefalomielitis aguda diseminada. Protocolo de diagnóstico y tratamiento. Canarias pediátrica.2020; 39(1):20-25. https://scptfe.com/wp-content/uploads/2020/10/39-1-Encefalomielitis-aguda-diseminada.pdf

8. Lozano-Iraguen P, Arribas- Del Cmpo J, Castro- Pesce A, Morales- García C, Chiang- Odeh F, Pelayo- Varela C. Acute disseminated encephalomyelitis associated with SARS-CoV-2 infection without respiratory compromise. Rev Neurol. 2022; 75(2):45-48. http://doi:10.33588/rn.7502.2021335

9. Luis León C, García García RJ, Odales Ibarra R, Marrero Martínez P. Encefalomielitis diseminada aguda recurrente, asciada a citomegalovirus en una adolescente inmunocompetente. Rev Cubana Pediatr. 2017; 89(3). http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312017000300013

10. Corrales Arroyo MJ, López Gallardo G. Encefalomielitis Aguda Diseminada: Formas de Presentación y Espectro Clínico. Serie de Casos. Rev. Ecuat. Neurol.2011; 20 :( 1-3). https://revecuatneurol.com/magazine_issue_article/encefalomielitis-aguda-diseminada-presentacion-espectro-casos/

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Published

2023-10-08

How to Cite

1.
Garzón Cutiño L, Olivera Vega M, González García S, García Hernández K, Torres Campo L. Acute disseminated encephalomyelitis and not-associated active viral infection. Salud, Ciencia y Tecnología - Serie de Conferencias [Internet]. 2023 Oct. 8 [cited 2025 Feb. 4];2:450. Available from: https://conferencias.ageditor.ar/index.php/sctconf/article/view/369